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Plasma concentrations of lidocaine in dogs following lidocaine patch application over an incision compared to intact skin.

Authors :
Joudrey SD
Robinson DA
Kearney MT
Papich MG
da Cunha AF
Source :
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2015 Dec; Vol. 38 (6), pp. 575-80. Date of Electronic Publication: 2015 Apr 03.
Publication Year :
2015

Abstract

The objective was to compare plasma lidocaine concentrations when a commercially available 5% lidocaine patch was placed on intact skin vs. an incision. Our hypothesis was that greater absorption of lidocaine would occur from the incision site compared to intact skin. Ten dogs were used in a crossover design. A patch was placed over an incision, and then after a washout period, a patch was placed over intact skin. Plasma lidocaine concentrations were measured at patch placement; 20, 40 and 60 min; and 2, 4, 6, 12, 24, 36, 48, 72 and 96 h after patch placement. After patch removal, the skin was graded using a subjective skin reaction system. No dogs required rescue analgesia, and no toxicity or skin reaction was noted. Mean ± SD AUC and CMAX were 3054.29 ± 1095.93 ng·h/mL and 54.1 ± 15.84 ng/mL in the Incision Group, and 2269.9 ± 1037.08 ng·h/mL and 44.5 ± 16.34 ng/mL in the No-Incision Group, respectively. The AUC was significantly higher in the Incision Group. The results of the study demonstrate that the actual body exposure to lidocaine was significantly higher when an incision was present compared to intact skin. No adverse effects were observed from either treatment. Efficacy was not evaluated.<br /> (© 2015 John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1365-2885
Volume :
38
Issue :
6
Database :
MEDLINE
Journal :
Journal of veterinary pharmacology and therapeutics
Publication Type :
Academic Journal
Accession number :
25846945
Full Text :
https://doi.org/10.1111/jvp.12224