Back to Search
Start Over
Matters of fiber size and myonuclear domain: Does size matter more than age?
- Source :
-
Muscle & nerve [Muscle Nerve] 2015 Dec; Vol. 52 (6), pp. 1040-6. Date of Electronic Publication: 2015 Sep 28. - Publication Year :
- 2015
-
Abstract
- Introduction: The relationship between fiber size and myonuclear content is poorly understood.<br />Methods: Biopsy cross-sections from young and old trained and untrained healthy individuals were analyzed for fiber area and myonuclei, and 2 fiber-size-dependent cluster analyses were performed.<br />Results: When comparing fibers of similar size, no effect of training or age was found for myonuclear domain. There was a linear relationship between fiber area and myonuclei per fiber (r = 0.99; P < 0.001) and a non-linear relationship between fiber area and domain (r = 0.97-0.99; P < 0.0001), with a markedly smaller domain in fibers <3,000 µm(2). A higher proportion of type II fibers <3,000 µm(2) was observed in the old subjects.<br />Conclusions: These findings suggest that age-related reductions in myonuclear domain size could be explained by the greater proportion of small fibers. The data also highlight the usefulness of determining fiber-size-based clusters for gaining mechanistic insight into the relationship between skeletal muscle fiber size and myonuclear content.<br /> (© 2015 Wiley Periodicals, Inc.)
Details
- Language :
- English
- ISSN :
- 1097-4598
- Volume :
- 52
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Muscle & nerve
- Publication Type :
- Academic Journal
- Accession number :
- 25845994
- Full Text :
- https://doi.org/10.1002/mus.24669