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Intratumoral macrophage phenotype and CD8+ T lymphocytes as potential tools to predict local tumor outgrowth at the intervention site in malignant pleural mesothelioma.
- Source :
-
Lung cancer (Amsterdam, Netherlands) [Lung Cancer] 2015 Jun; Vol. 88 (3), pp. 332-7. Date of Electronic Publication: 2015 Mar 21. - Publication Year :
- 2015
-
Abstract
- Objectives: In patients with malignant pleural mesothelioma (MPM), local tumor outgrowth (LTO) after invasive procedures is a well-known complication. Currently, no biomarker is available to predict the occurrence of LTO. This study aims to investigate whether the tumor macrophage infiltration and phenotype of and/or the infiltration of CD8+ T-cells predicts LTO.<br />Materials and Methods: Ten mesothelioma patients who developed LTO were clinically and pathologically matched with 10 non-LTO mesothelioma patients. Immunohistochemistry was performed on diagnostic biopsies to determine the total TAM (CD68), the M2 TAM (CD163) and CD8+ T-cell count (CD8).<br />Results: The mean M2/total TAM ratio differed between the two groups: 0.90±0.09 in the LTO group versus 0.63±0.09 in patients without LTO (p<0.001). In addition, the mean CD8+ T-cell count was significantly different between the two groups: 30 per 0.025 cm2 (range 2-60) in the LTO group and 140 per 0.025 cm2 (range 23-314) in the patients without LTO (p<0.01).<br />Conclusion: This study shows that patients who develop LTO after a local intervention have a higher M2/total TAM ratio and lower CD8+ cell count at diagnosis compared to patients who did not develop this outgrowth. We propose that the M2/total TAM ratio and the CD8+ T-cell amount are potential tools to predict which MPM patients are prone to develop LTO.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers
Cell Count
Female
Humans
Immunohistochemistry
Lung Neoplasms drug therapy
Lung Neoplasms mortality
Lymphocytes, Tumor-Infiltrating immunology
Lymphocytes, Tumor-Infiltrating pathology
Macrophages metabolism
Male
Mesothelioma drug therapy
Mesothelioma mortality
Mesothelioma, Malignant
Middle Aged
Neoplasm Staging
Phenotype
Pleural Neoplasms drug therapy
Pleural Neoplasms mortality
Prognosis
Tomography, X-Ray Computed
Treatment Outcome
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes pathology
Lung Neoplasms immunology
Lung Neoplasms pathology
Macrophages immunology
Macrophages pathology
Mesothelioma immunology
Mesothelioma pathology
Pleural Neoplasms immunology
Pleural Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8332
- Volume :
- 88
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 25843042
- Full Text :
- https://doi.org/10.1016/j.lungcan.2015.03.013