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Stability of chitosan-a challenge for pharmaceutical and biomedical applications.
- Source :
-
Marine drugs [Mar Drugs] 2015 Apr 01; Vol. 13 (4), pp. 1819-46. Date of Electronic Publication: 2015 Apr 01. - Publication Year :
- 2015
-
Abstract
- Chitosan-one of the natural multifunctional polymers-due to its unique and versatile biological properties is regarded as a useful compound in medical and pharmaceutical technology. Recently, considerable research effort has been made in order to develop safe and efficient chitosan products. However, the problem of poor stability of chitosan-based systems restricts its practical applicability; thus, it has become a great challenge to establish sufficient shelf-life for chitosan formulations. Improved stability can be assessed by controlling the environmental factors, manipulating processing conditions (e.g., temperature), introducing a proper stabilizing compound, developing chitosan blends with another polymer, or modifying the chitosan structure using chemical or ionic agents. This review covers the influence of internal, environmental, and processing factors on the long-term stability of chitosan products. The aim of this paper is also to highlight the latest developments which enable the physicochemical properties of chitosan-based applications to be preserved upon storage.
- Subjects :
- Animals
Carbohydrate Sequence
Chitosan adverse effects
Chitosan chemistry
Cross-Linking Reagents chemistry
Drug Stability
Drug Storage
Excipients adverse effects
Hot Temperature adverse effects
Humans
Hydrolysis
Molecular Weight
Tissue Scaffolds adverse effects
Chitosan analogs & derivatives
Drug Compounding trends
Drug Delivery Systems adverse effects
Drug Delivery Systems trends
Excipients chemistry
Tissue Engineering trends
Tissue Scaffolds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 25837983
- Full Text :
- https://doi.org/10.3390/md13041819