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The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations.
- Source :
-
Journal of behavioral medicine [J Behav Med] 2015 Aug; Vol. 38 (4), pp. 609-19. Date of Electronic Publication: 2015 Apr 03. - Publication Year :
- 2015
-
Abstract
- This study investigated whether inflammation may explain the relationship between depression and incident cardiovascular hospitalisations. Participants (55-85 years) completed baseline depression and physical assessment. Those without self-reported cardiovascular events were followed prospectively for hospital admissions for angina, myocardial infarction and cerebral infarction (median 937 days). Across 5140 person-years of risk (N = 1692), there were 47 incident cardiovascular hospitalisations (2.8 %). Controlling for age and gender, interleukin (IL)-6, C-reactive protein (CRP), body mass index (BMI) and waist-to-hip ratio were associated with future cardiovascular events. Mediation analysis showed that CRP accounted for 8.1 % and IL-6 10.9 % of the effect of depression on cardiovascular events, and including the indirect effect in the model substantially reduced the direct relationship between depression and cardiovascular hospitalisations. BMI and waist-to-hip ratio accounted for indirect effects of 7.7 and 10.4 %, respectively. Inflammatory markers partly explain the association between depression and cardiovascular events, although other shared factors also likely contribute.
- Subjects :
- Aged
Aged, 80 and over
Biomarkers blood
Body Mass Index
Cardiovascular Diseases complications
Cardiovascular Diseases psychology
Depression complications
Depression psychology
Depressive Disorder blood
Depressive Disorder complications
Depressive Disorder psychology
Female
Humans
Inflammation complications
Inflammation psychology
Male
Middle Aged
Risk Factors
Waist-Hip Ratio
C-Reactive Protein metabolism
Cardiovascular Diseases blood
Depression blood
Hospitalization
Inflammation blood
Interleukin-6 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1573-3521
- Volume :
- 38
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of behavioral medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25835436
- Full Text :
- https://doi.org/10.1007/s10865-015-9637-2