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Primary biliary cirrhosis-associated hepatocellular carcinoma in Chinese patients: incidence and risk factors.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2015 Mar 28; Vol. 21 (12), pp. 3554-63. - Publication Year :
- 2015
-
Abstract
- Aim: To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma (HCC) in Chinese patients with primary biliary cirrhosis (PBC).<br />Methods: We reviewed the data of 52 PBC-associated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence and characteristics between the two genders. The risk factors for PBC-associated HCC were analyzed via a case-control study comprising 20 PBC patients with HCC and 77 matched controls without HCC. The matched factors included gender, age, follow-up period and Child-Pugh scores. Conditional logistic regression was used to evaluate the odds ratios of potential risk factors for HCC development. A P < 0.05 was considered statistically significant.<br />Results: The incidence of HCC in Chinese PBC patients was 4.13% (52/1255) and was significantly higher in the males (9.52%) than in the females (3.31%). Among the 52 PBC patients with HCC, 55.76% (29/52) were diagnosed with HCC and PBC simultaneously, and 5.76% (3/52) were diagnosed with HCC before PBC. The males with PBC-associated HCC were more likely than the females to have undergone blood transfusion (18.75% vs 8.33%, P = 0.043), consumed alcohol (31.25% vs 8.33%, P = 0.010), smoked (31.25% vs 8.33%, P = 0.010), had a family history of malignancy (25% vs 5.56%, P = 0.012), and had serious liver inflammation, as indicated by the elevated levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase (P < 0.05). Conditional logistic regression analysis revealed that body mass index (BMI) ≥ 25 [adjusted odds ratio (AOR) = 1.116, 95%CI: 1.002-1.244, P = 0.045] and history of alcohol intake (AOR = 10.294, 95%CI: 1.108-95.680, P = 0.040) were significantly associated with increased odds of HCC development in PBC patients.<br />Conclusion: HCC is not rare in Chinese PBC patients. Risk factors for PBC-associated HCC include BMI ≥ 25 and a history of alcohol intake. In addition to regular monitoring, PBC patients may benefit from abstinence from alcohol and body weight control.
- Subjects :
- Aged
Alcohol Drinking adverse effects
Alcohol Drinking epidemiology
Body Mass Index
Carcinoma, Hepatocellular diagnosis
Chi-Square Distribution
China epidemiology
Female
Humans
Incidence
Kaplan-Meier Estimate
Liver Cirrhosis, Biliary diagnosis
Liver Neoplasms diagnosis
Logistic Models
Male
Middle Aged
Obesity diagnosis
Obesity epidemiology
Odds Ratio
Retrospective Studies
Risk Factors
Asian People
Carcinoma, Hepatocellular epidemiology
Liver Cirrhosis, Biliary epidemiology
Liver Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 21
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25834320
- Full Text :
- https://doi.org/10.3748/wjg.v21.i12.3554