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An ancestral bacterial division system is widespread in eukaryotic mitochondria.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Aug 18; Vol. 112 (33), pp. 10239-46. Date of Electronic Publication: 2015 Mar 23. - Publication Year :
- 2015
-
Abstract
- Bacterial division initiates at the site of a contractile Z-ring composed of polymerized FtsZ. The location of the Z-ring in the cell is controlled by a system of three mutually antagonistic proteins, MinC, MinD, and MinE. Plastid division is also known to be dependent on homologs of these proteins, derived from the ancestral cyanobacterial endosymbiont that gave rise to plastids. In contrast, the mitochondria of model systems such as Saccharomyces cerevisiae, mammals, and Arabidopsis thaliana seem to have replaced the ancestral α-proteobacterial Min-based division machinery with host-derived dynamin-related proteins that form outer contractile rings. Here, we show that the mitochondrial division system of these model organisms is the exception, rather than the rule, for eukaryotes. We describe endosymbiont-derived, bacterial-like division systems comprising FtsZ and Min proteins in diverse less-studied eukaryote protistan lineages, including jakobid and heterolobosean excavates, a malawimonad, stramenopiles, amoebozoans, a breviate, and an apusomonad. For two of these taxa, the amoebozoan Dictyostelium purpureum and the jakobid Andalucia incarcerata, we confirm a mitochondrial localization of these proteins by their heterologous expression in Saccharomyces cerevisiae. The discovery of a proteobacterial-like division system in mitochondria of diverse eukaryotic lineages suggests that it was the ancestral feature of all eukaryotic mitochondria and has been supplanted by a host-derived system multiple times in distinct eukaryote lineages.
- Subjects :
- Adenosine Triphosphatases metabolism
Arabidopsis genetics
Bacteria cytology
Bacterial Proteins metabolism
Base Sequence
Cell Cycle Proteins metabolism
Cell Division
Databases, Genetic
Dictyostelium metabolism
Escherichia coli Proteins metabolism
Evolution, Molecular
Likelihood Functions
Molecular Sequence Data
Phylogeny
Plastids metabolism
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae metabolism
Bacterial Proteins genetics
Cytoskeletal Proteins genetics
DNA, Bacterial genetics
Mitochondria metabolism
Mitochondrial Dynamics
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 112
- Issue :
- 33
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 25831547
- Full Text :
- https://doi.org/10.1073/pnas.1421392112