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Gender differences in depressive symptom profiles and patterns of psychotropic drug usage in Asian patients with depression: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants study.
- Source :
-
The Australian and New Zealand journal of psychiatry [Aust N Z J Psychiatry] 2015 Sep; Vol. 49 (9), pp. 833-41. Date of Electronic Publication: 2015 Mar 31. - Publication Year :
- 2015
-
Abstract
- Objectives: The purpose of this study was to investigate whether there were gender-specific depressive symptom profiles or gender-specific patterns of psychotropic agent usage in Asian patients with depression.<br />Method: Clinical data from the Research on Asian Psychotropic Prescription Patterns for Antidepressant study (1171 depressed patients) were used to determine gender differences by analysis of covariates for continuous variables and by logistic regression analysis for discrete variables. In addition, a binary logistic regression model was fitted to identify independent clinical correlates of the gender-specific pattern on psychotropic drug usage.<br />Results: Men were more likely than women to have loss of interest (adjusted odds ratio = 1.379, p = 0.009), fatigue (adjusted odds ratio = 1.298, p = 0.033) and concurrent substance abuse (adjusted odds ratio = 3.793, p = 0.008), but gender differences in other symptom profiles and clinical features were not significant. Men were also more likely than women to be prescribed adjunctive therapy with a second-generation antipsychotic (adjusted odds ratio = 1.320, p = 0.044). However, men were less likely than women to have suicidal thoughts/acts (adjusted odds ratio = 0.724, p = 0.028). Binary logistic regression models revealed that lower age (odds ratio = 0.986, p = 0.027) and current hospitalization (odds ratio = 3.348, p < 0.0001) were independent clinical correlates of use of second-generation antipsychotics as adjunctive therapy for treating depressed Asian men.<br />Conclusion: Unique gender-specific symptom profiles and gender-specific patterns of psychotropic drug usage can be identified in Asian patients with depression. Hence, ethnic and cultural influences on the gender preponderance of depression should be considered in the clinical psychiatry of Asian patients.<br /> (© The Royal Australian and New Zealand College of Psychiatrists 2015.)
- Subjects :
- Adult
Aged
Antidepressive Agents therapeutic use
Antipsychotic Agents therapeutic use
China epidemiology
Depression drug therapy
Depression epidemiology
Depressive Disorder, Major drug therapy
Depressive Disorder, Major epidemiology
Fatigue epidemiology
Female
Hong Kong epidemiology
Humans
India epidemiology
Indonesia epidemiology
Japan epidemiology
Logistic Models
Malaysia epidemiology
Male
Middle Aged
Odds Ratio
Republic of Korea epidemiology
Sex Distribution
Sex Factors
Singapore epidemiology
Substance-Related Disorders epidemiology
Suicidal Ideation
Suicide, Attempted psychology
Suicide, Attempted statistics & numerical data
Taiwan epidemiology
Thailand epidemiology
Asian People psychology
Depression psychology
Depressive Disorder, Major psychology
Fatigue psychology
Substance-Related Disorders psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1614
- Volume :
- 49
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Australian and New Zealand journal of psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 25829482
- Full Text :
- https://doi.org/10.1177/0004867415579464