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Convenient recycling and reuse of bombarded [¹⁸O]H₂O for the production and the application of [¹⁸F]F⁻.
- Source :
-
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2015 Jul; Vol. 101, pp. 44-52. Date of Electronic Publication: 2015 Mar 11. - Publication Year :
- 2015
-
Abstract
- The limited availability and the increasing demands of [(18)O]H2O force the reuse of bombarded [(18)O]H2O for the production of [(18)F]F(-) at least for the purposes of research. Therefore, inorganic and organic contaminants have to be removed from the [(18)O]H2O after bombardment. We present a simple, effective, easy-handling and reliable method of [(18)O]H2O purification including oxidation and distillation. The obtained recycled [(18)O]H2O had comparable quality to commercially distributed [(18)O]water. This was confirmed by a detailed comparison of produced radionuclides and their activities and the application of [(18)F]F(-) for the automated synthesis of [(18)F]fluspidine.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Benzofurans chemical synthesis
Benzofurans isolation & purification
Distillation instrumentation
Distillation methods
Drug Contamination
Equipment Reuse
Humans
Oxidation-Reduction
Piperidines chemical synthesis
Piperidines isolation & purification
Positron-Emission Tomography
Radiopharmaceuticals isolation & purification
Spectrometry, Gamma
Fluorine Radioisotopes chemistry
Oxygen Isotopes chemistry
Radiopharmaceuticals chemical synthesis
Water chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9800
- Volume :
- 101
- Database :
- MEDLINE
- Journal :
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25827947
- Full Text :
- https://doi.org/10.1016/j.apradiso.2015.03.009