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Isolated MYC cytogenetic abnormalities in diffuse large B-cell lymphoma do not predict an adverse clinical outcome.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2015; Vol. 56 (11), pp. 3082-9. Date of Electronic Publication: 2015 May 12. - Publication Year :
- 2015
-
Abstract
- In this study, we investigated the significance of MYC, BCL2 and BCL6 gene abnormalities in a cohort of 205 diffuse large B-cell lymphoma (DLBCL) patients studied by conventional and/or fluorescence in situ hybridization cytogenetic analysis. Combining these methods, 172 cases (84%) were classified as MYC-, 17 (8%) were MYC+/BCL2-/BCL6-, and 16 (8%) were double/triple-hit lymphomas (i.e. MYC+/BCL2+, MYC+/BCL6+, or MYC+/BCL2+/BCL6+). We found a significant difference in event-free survival (EFS) among the three groups (p = 0.02), with the double/triple-hit group having the worst EFS. Patients who were MYC+, but BCL2- and BCL6-, had the best EFS. We conclude that patients with MYC+ DLBCL, but without BCL2 or BCL6 abnormalities, do not have a worse outcome when compared to those who are MYC-. However, patients with double/triple-hit DLBCL have a very poor outcome and should be treated with aggressive or novel therapies.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor
Chromosome Banding
Female
Gene Rearrangement, B-Lymphocyte
Genes, bcl-2
Humans
In Situ Hybridization, Fluorescence
Lymphoma, Large B-Cell, Diffuse drug therapy
Lymphoma, Large B-Cell, Diffuse pathology
Male
Middle Aged
Neoplasm Staging
Prognosis
Proto-Oncogene Proteins c-bcl-6 genetics
Survival Analysis
Treatment Outcome
Young Adult
Chromosome Aberrations
Genes, myc
Lymphoma, Large B-Cell, Diffuse genetics
Lymphoma, Large B-Cell, Diffuse mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 56
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 25827211
- Full Text :
- https://doi.org/10.3109/10428194.2015.1034699