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A comparative study of 18F-FDG PET/CT and ultrasonography in the diagnosis of breast cancer and axillary lymph node metastasis.
- Source :
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The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.. [Q J Nucl Med Mol Imaging] 2017 Dec; Vol. 61 (4), pp. 429-437. Date of Electronic Publication: 2015 Mar 31. - Publication Year :
- 2017
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Abstract
- Background: The aim of this study was to compare the diagnostic value of 18F-FDG-PET/CT (PET/CT) with ultrasonography (US) in detection of primary breast cancer and axillary lymph nodes (ALN) metastasis of breast cancer.<br />Methods: One hundred and sixty four patients with breast carcinoma were recruited and analyzed retrospectively. All patients underwent PET-CT and US. The PET/CT scan results for the diagnosis of primary breast cancer were compared with US. The diagnostic accuracy of PET/CT in detecting ALN metastasis was compared with histopathology.<br />Results: In 164 patients with cytologically established breast carcinoma, the sensitivity of PET/CT and US in the diagnosis of breast cancer were 86% (141/164), 91% (149/164), respectively. The sensitivity, specificity of PET/CT and US in ALN staging were 46% and 54%, 91% and 91%, respectively. The diagnostic accuracy of PET/CT correlated with the ALN size, the SUVmax of primary breast cancer (P=0.02 and 0.04).<br />Conclusions: PET/CT is very expensive, and not superior to US in detection of primary breast cancer and in ALN staging, but superior in detecting distant metastases. PET/CT cannot be recommended as a primary diagnostic procedure in early breast cancer. US should still remain the first line for the diagnosis of stage I breast cancer. In relation to the detection of axillary node metastases, both PET/CT and ultrasonography have poor sensitivity, and cannot replace staging by using the sentinel node procedure.
- Subjects :
- Adult
Aged
Axilla
Breast Neoplasms diagnostic imaging
Breast Neoplasms pathology
Female
Humans
Lymph Nodes pathology
Middle Aged
Multimodal Imaging methods
Retrospective Studies
Sensitivity and Specificity
Young Adult
Breast Neoplasms diagnosis
Fluorodeoxyglucose F18 chemistry
Lymph Nodes diagnostic imaging
Lymphatic Metastasis diagnostic imaging
Positron Emission Tomography Computed Tomography methods
Radiopharmaceuticals chemistry
Ultrasonography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1827-1936
- Volume :
- 61
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..
- Publication Type :
- Academic Journal
- Accession number :
- 25823388
- Full Text :
- https://doi.org/10.23736/S1824-4785.17.02785-6