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Expression of regulatory dendritic cell-related cytokines in cattle experimentally infected with Trypanosoma evansi.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2015 Aug; Vol. 77 (8), pp. 1017-9. Date of Electronic Publication: 2015 Mar 27. - Publication Year :
- 2015
-
Abstract
- Trypanosoma evansi causes wasting disease in many livestock. T. evansi infection gives rise to inflammatory immune responses, which contribute to the development of inflammation-associated tissue injury. We previously reported that regulatory dendritic cells (DCs), which act as potential regulators of inflammation, were activated in infected mice and transfer of regulatory DCs to infected mice prolonged their survival. However, the kinetics of regulatory DCs in cattle, which are natural hosts of T. evansi, remained unclear. In this study, we report that the expressions of CCL8 and IL-10, which promote the development of regulatory DCs, were up-regulated in cattle experimentally infected with T. evansi. This finding is potentially useful for studying the control strategy of T. evansi infection in cattle.
- Subjects :
- Animals
Cattle immunology
Cattle parasitology
Chemokine CCL8 blood
Chemokine CCL8 physiology
Cytokines blood
Interleukin-10 blood
Interleukin-10 physiology
Male
Real-Time Polymerase Chain Reaction veterinary
Trypanosomiasis, Bovine parasitology
Cytokines physiology
Dendritic Cells physiology
Trypanosoma immunology
Trypanosomiasis, Bovine immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 77
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 25819543
- Full Text :
- https://doi.org/10.1292/jvms.15-0066