Efficacy of tobramycin aerosol in nasal polyposis.

Authors :: Bonfils P
Escabasse V
Coste A
Gilain L
Louvrier C
Serrano E
de Bonnecaze G
Mortuaire G
Chevalier D
Laccourreye O
Mainardi JL
Source :: European annals of otorhinolaryngology, head and neck diseases [Eur Ann Otorhinolaryngol Head Neck Dis] 2015 Jun; Vol. 132 (3), pp. 119-23. Date of Electronic Publication: 2015 Mar 23.
Publication Year :: 2015
Abstract: Context: Treatment of infected nasal polyposis.<br />Material and Methods: Multicenter interventional prospective double-blind randomized study with matched groups: treatment with tobramycin aerosol versus isotonic saline aerosol. The study population included 55 patients: 23 receiving isotonic saline aerosol and 32 receiving tobramycin. A novel device (Easynose®) was used with an original principle limiting pulmonary deposition and ensuring homogeneous peripheral deposition in the nasal cavities.<br />Objectives: The principal objective was to compare bacteriological eradication between tobramycin 150mg/3ml versus isotonic saline, both administered by nebulization via the Easynose® device.<br />Results and Conclusion: Tobramycin aerosol administered via the Easynose® device showed significantly better bacteriological eradication than isotonic saline.<br /> (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)