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Formulation, characterization, and evaluation of ligand-conjugated biodegradable quercetin nanoparticles for active targeting.
- Source :
-
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2016 May; Vol. 44 (3), pp. 960-70. Date of Electronic Publication: 2015 Mar 27. - Publication Year :
- 2016
-
Abstract
- The aim of this study was to design a targeted drug delivery system carrying a natural anticancer drug Quercetin (Qu), specifically for skin cancer. A central composite design was applied separately for each ligand, and the quadratic model was used for the process. The surface morphology was confirmed by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR), and in vitro release studies were also performed. The MTT assay was performed against two different cell lines, to measure their anticancer potentials and their targeting ability. The study thus reveals that MA-Qu-PLGA and FA-Qu-PLGA nanoparticles (NPs) can be used as effective drug delivery systems for skin cancer treatment encompassing natural drugs.
- Subjects :
- Cell Line, Tumor
Humans
Skin Neoplasms metabolism
Skin Neoplasms pathology
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacokinetics
Antineoplastic Agents pharmacology
Drug Delivery Systems methods
Nanoparticles chemistry
Quercetin chemistry
Quercetin pharmacokinetics
Quercetin pharmacology
Skin Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2169-141X
- Volume :
- 44
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Artificial cells, nanomedicine, and biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 25813566
- Full Text :
- https://doi.org/10.3109/21691401.2015.1008503