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Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Apr 15; Vol. 25 (8), pp. 1700-1704. Date of Electronic Publication: 2015 Mar 12. - Publication Year :
- 2015
-
Abstract
- A series of 2-phenyl- or 3-phenyl piperazines, structurally related to DM235 and DM232, two potent nootropic agents, have been prepared and tested in the mouse passive-avoidance test, to assess their ability to revert scopolamine-induced amnesia. Although the newly synthesized molecules were less potent than the parent compounds, some useful information has been obtained from structure-activity relationships. A small but significant enantioselectivity has been found for the most potent compound 5a.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Amnesia chemically induced
Amnesia drug therapy
Animals
Avoidance Learning drug effects
Mice
Nootropic Agents pharmacology
Nootropic Agents therapeutic use
Piperazines pharmacology
Piperazines therapeutic use
Pyrroles chemistry
Stereoisomerism
Structure-Activity Relationship
Nootropic Agents chemistry
Piperazines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 25813160
- Full Text :
- https://doi.org/10.1016/j.bmcl.2015.03.009