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Cellular differentiation of epithelioid sarcoma. An electron-microscopic, enzyme-histochemical, and immunohistochemical study.
- Source :
-
The American journal of pathology [Am J Pathol] 1985 Apr; Vol. 119 (1), pp. 44-56. - Publication Year :
- 1985
-
Abstract
- For the purpose of clarifying cellular differentiation of epithelioid sarcoma, studies based on various methods were performed. Enzyme histochemical studies showed that epithelioid sarcoma tumor cells have characteristics intermediate between epithelial cells and the large plump cells of synovial sarcoma-incomplete epithelial differentiation. For alkaline phosphatase and adenosine triphosphatase particularly, positive cells and negative cells coexisted, as in the large plump cells of synovial sarcoma. Immunohistochemical studies for alpha 1-antitrypsin, alpha 1-antichymotrypsin, vimentin, and keratin also showed that epithelioid sarcoma tumor cells are very similar to the large plump cells of synovial sarcoma and have incomplete epithelial differentiation. For example, the examinations of serial sections and double staining methods revealed that keratin-positive cells are always vimentin-positive in epithelioid sarcoma and in the monophasic area of synovial sarcoma. Electron-microscopically, bundles of intermediate filaments and filopodia toward the intercellular lumen were observed, as in the monophasic area of synovial sarcoma. The results of enzyme-histochemical and immunohistochemical studies of non-neoplastic synovial lining cells, performed here for the first time, are also discussed.
- Subjects :
- Adenosine Triphosphatases metabolism
Adult
Alkaline Phosphatase metabolism
Cell Transformation, Neoplastic pathology
Female
Fibroma pathology
Fibroma ultrastructure
Humans
Keratins metabolism
Male
Microscopy, Electron
Middle Aged
Sarcoma ultrastructure
Sarcoma, Synovial pathology
Sarcoma, Synovial ultrastructure
Staining and Labeling
Vimentin metabolism
Sarcoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9440
- Volume :
- 119
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 2580443