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Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in Border disease virus-infected small ruminants.
- Source :
-
PloS one [PLoS One] 2015 Mar 23; Vol. 10 (3), pp. e0120005. Date of Electronic Publication: 2015 Mar 23 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Border Disease (BD), caused by Pestivirus from the family Flaviviridae, leads to serious reproductive losses and brain anomalies such as hydranencephaly and cerebellar hypoplasia in aborted fetuses and neonatal lambs. In this report it is aimed to investigate the expression of neuronal nitric oxide synthase (nNOS), A Disintegrin And Metalloprotease with Thrombospondin type I repeats-13 (ADAMTS-13), and neurofilament (NF) in the brain tissue in small ruminants infected with Border Disease Virus (BDV) and to identify any correlation between hypomyelinogenesis and BD neuropathology. Results of the study revealed that the levels of ADAMTS-13 (p<0.05), nNOS (p<0.05), and NF (p<0.05) were remarkably higher in BDV-infected brain tissue than in the uninfected control. It was suggested that L-arginine-NO synthase pathway is activated after infection by BDV and that the expression of NF and nNOS is associated with the severity of BD. A few studies have focused on ADAMTS-13 expression in the central nervous system, and its function continues to remain unclear. The most prominent finding from our study was that ADAMTS-13, which contain two CUB domains, has two CUB domains and its high expression levels are probably associated with the development of the central nervous system (CNS). The results also clearly indicate that the interaction of ADAMTS-13 and NO may play an important role in the regulation and protection of the CNS microenvironment in neurodegenerative diseases. In addition, NF expression might indicate the progress of the disease. To the best of the authors'knowledge, this is the first report on ADAMTS-13 expression in the CNS of BDV-infected small ruminants.
- Subjects :
- Animals
Antigens, Viral metabolism
Border Disease pathology
Border Disease physiopathology
Border disease virus immunology
Brain metabolism
Brain pathology
Brain physiopathology
Gene Expression Regulation, Enzymologic
Goat Diseases metabolism
Goat Diseases pathology
Goat Diseases physiopathology
Myelin Sheath physiology
Sheep Diseases metabolism
Sheep Diseases pathology
Sheep Diseases physiopathology
ADAM Proteins metabolism
Border Disease metabolism
Border disease virus physiology
Goats virology
Intermediate Filaments metabolism
Nitric Oxide Synthase Type I metabolism
Sheep virology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25799514
- Full Text :
- https://doi.org/10.1371/journal.pone.0120005