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Gene regulatory mechanisms orchestrated by p63 in epithelial development and related disorders.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2015 Jun; Vol. 1849 (6), pp. 590-600. Date of Electronic Publication: 2015 Mar 19. - Publication Year :
- 2015
-
Abstract
- The transcription factor p63 belongs to the p53 family and is a key regulator in epithelial commitment and development. Mutations in p63 give rise to several epithelial related disorders with defects in skin, limb and orofacial structures. Since the discovery of p63, efforts have been made to identify its target genes using individual gene approaches and to understand p63 function in normal epithelial development and related diseases. Recent genome-wide approaches have identified tens of thousands of potential p63-regulated target genes and regulatory elements, and reshaped the concept of gene regulation orchestrated by p63. These data also provide insights into p63-related disease mechanisms. In this review, we discuss the regulatory role of p63 in normal and diseased epithelial development in light of these novel findings. We also propose future perspectives for dissecting the molecular mechanism of p63-mediated epithelial development and related disorders as well as for potential therapeutic strategies.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Epithelium growth & development
Gene Expression Regulation, Developmental
Gene Targeting
Genetic Diseases, Inborn genetics
Genetic Diseases, Inborn pathology
Humans
Membrane Proteins biosynthesis
Membrane Proteins metabolism
DNA-Binding Proteins genetics
Epithelium metabolism
Gene Regulatory Networks
Membrane Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1849
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 25797018
- Full Text :
- https://doi.org/10.1016/j.bbagrm.2015.03.003