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Weighing the proteasome for covalent modifications.
- Source :
-
Chemistry & biology [Chem Biol] 2015 Mar 19; Vol. 22 (3), pp. 315-6. - Publication Year :
- 2015
-
Abstract
- Posttranslational modifications (PTMs) control protein function, but established peptide-based proteomic methods often fail to provide a comprehensive view of PTMs. In this issue of Chemistry & Biology, Gersch et al. describe an efficient combination of chromatographic separation and top-down mass spectrometry that together with an intuitive visualization tool allowed them to screen the proteasome for PTMs and covalently binding inhibitors.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-1301
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Chemistry & biology
- Publication Type :
- Academic Journal
- Accession number :
- 25794435
- Full Text :
- https://doi.org/10.1016/j.chembiol.2015.03.003