Back to Search
Start Over
Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Apr 15; Vol. 23 (8), pp. 1849-57. Date of Electronic Publication: 2015 Feb 21. - Publication Year :
- 2015
-
Abstract
- The synthesis and biological analysis of a number of novel congeners of the aminocyclopentitol pactamycin is described. Specific attention was paid to the preparation of derivatives at crucial synthetic branch points of the parent structure, and biological assays revealed a number of insights into the source of pactamycin's biological activity. Additionally, the encapsulation of pactamycin and select derivatives into the PRINT© nanoparticle technology was investigated as a proof-of-concept, and evidence of bioactivity modulation through nanoparticle delivery is demonstrated. This work has provided heretofore unrealized access to a large number of novel compounds for further evaluation.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents administration & dosage
Cell Line, Tumor
Drug Carriers chemistry
Humans
Nanoparticles chemistry
Neoplasms drug therapy
Pactamycin administration & dosage
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Pactamycin analogs & derivatives
Pactamycin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 23
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25792144
- Full Text :
- https://doi.org/10.1016/j.bmc.2015.02.022