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Syphilitic uveitis and optic neuritis in Sydney, Australia.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2015 Sep; Vol. 99 (9), pp. 1215-9. Date of Electronic Publication: 2015 Mar 18. - Publication Year :
- 2015
-
Abstract
- Aims: To describe ocular syphilis presentations to a tertiary referral eye hospital over a 5-year period and to document HIV coinfection frequency.<br />Methods: A retrospective chart review was conducted of consecutive ocular syphilis presentations to Sydney Eye Hospital from 2007 to 2012. Inclusion criteria were positive syphilis serology, ocular inflammation on clinical examination and appropriate syphilis treatment. Outcome measures were clinical features at presentation and best-corrected visual acuity (BCVA) at interval follow-up.<br />Results: Thirty-seven eyes of 25 patients were included in the series. Patients were predominantly male (92.0%, p<0.05) with mean age 43.7±14.0 years. Eight (32.0%) patients had confirmed HIV coinfection, three newly diagnosed with HIV. Twelve (32.4%) eyes demonstrated anterior segment involvement with anterior uveitis. Twenty-five (67.6%) eyes demonstrated posterior segment involvement, including panuveitis, acute syphilitic posterior placoid chorioretinitis, retinitis, necrotising retinitis, punctate retinitis and optic neuritis. There was a significant improvement in BCVA for involved eyes (p<0.05) at 1 month and 2-3 months follow-up.<br />Conclusions: The clinical findings of 37 eyes with ocular syphilis demonstrated a broad spectrum of clinical manifestations. Rates of HIV coinfection were high, with patients exhibiting both anterior and posterior segment inflammation. Visual outcome improved following syphilis treatment.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents therapeutic use
Australia
Chorioretinitis etiology
Chorioretinitis microbiology
Drug Therapy, Combination
Eye Infections, Bacterial drug therapy
Eye Infections, Bacterial microbiology
Female
HIV Infections complications
HIV Seropositivity
Humans
Male
Middle Aged
Optic Neuritis microbiology
Retrospective Studies
Syphilis drug therapy
Uveitis microbiology
Visual Acuity
Young Adult
Eye Infections, Bacterial complications
Optic Neuritis etiology
Syphilis complications
Uveitis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 99
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 25788666
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2014-306168