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Expression of Bcl-xL and Mcl-1 in the nonmelanoma skin cancers of renal transplant recipients.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2015 Apr; Vol. 143 (4), pp. 514-26. - Publication Year :
- 2015
-
Abstract
- Objectives: This study aims to investigate how immunosuppression influences the protein expression of antiapoptotic members of the Bcl-2 family-namely, Bcl-xL and Mcl-1-in nonmelanoma skin cancer (NMSC) and the peritumoral epidermis of renal transplant recipients.<br />Methods: NMSC and peritumoral epidermis protein expression of Bcl-xL and Mcl-1 were assessed by immunohistochemistry in renal transplant recipients receiving tacrolimus or sirolimus and the general population not receiving immunosuppression.<br />Results: NMSC from renal transplant recipients compared with patients not receiving immunosuppressant medications had a reduced Bcl-xL expression intensity (P = .042). Mcl-1 expression intensity in NMSC was decreased in tacrolimus-treated patients compared with sirolimus-treated patients and the nonimmunosuppressed population (P = .024). Bcl-xL expression intensity was increased in peritumoral epidermis compared with NMSC (P = .002).<br />Conclusions: It was shown for the first time that Bcl-xL and Mcl-1 expression are widespread in the peritumoral epidermis and NMSC of renal transplant recipients. Importantly in NMSC, Bcl-xL expression was reduced with immunosuppression exposure, and Mcl-1 expression was reduced in tacrolimus-treated compared with sirolimus-treated patients.<br /> (Copyright© by the American Society for Clinical Pathology.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Apoptosis
Carcinoma, Basal Cell pathology
Carcinoma, Squamous Cell pathology
Female
Humans
Immunohistochemistry
Kidney Transplantation
Male
Middle Aged
Mitosis
Sirolimus therapeutic use
Skin Neoplasms pathology
Tacrolimus therapeutic use
Transplant Recipients
Carcinoma, Basal Cell metabolism
Carcinoma, Squamous Cell metabolism
Immunosuppressive Agents therapeutic use
Myeloid Cell Leukemia Sequence 1 Protein metabolism
Skin Neoplasms metabolism
bcl-X Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 143
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25780003
- Full Text :
- https://doi.org/10.1309/AJCPQNB5WA3PLQBK