Back to Search
Start Over
Synthesis and biological screening of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyls as possible anti-tubercular and antimicrobial agents.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2015 Apr 13; Vol. 94, pp. 340-7. Date of Electronic Publication: 2015 Mar 07. - Publication Year :
- 2015
-
Abstract
- A series of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyl derivatives, 25-64 were synthesized and evaluated for inhibitory activity against Mycobacterium smegmatis MC(2) 155 strain and antimicrobial activities against four pathogenic bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Proteus vulgaris. Among them, compounds 40, 49, 50, and 54 exhibited moderate to good inhibition on the growth of the bacteria Mycobacterium smegmatis at the concentration of 30 μM. Compounds 26, 40, 44, 54 and 56 exhibited moderate to good antibacterial activity. Compound 5-(2'-(4-fluorobenzyl)thiazol-4'-yl)-2-(4-fluorophenyl)-4-methyl-thiazole (54) exhibited both antitubercular as well as antimicrobial activity against all tested strains.<br /> (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Bacillus subtilis drug effects
Dose-Response Relationship, Drug
Escherichia coli drug effects
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium smegmatis drug effects
Proteus vulgaris drug effects
Staphylococcus aureus drug effects
Structure-Activity Relationship
Thiazoles chemical synthesis
Thiazoles chemistry
Anti-Bacterial Agents pharmacology
Thiazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 94
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25778990
- Full Text :
- https://doi.org/10.1016/j.ejmech.2015.03.016