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Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2015 May 21; Vol. 13 (19), pp. 5385-90. - Publication Year :
- 2015
-
Abstract
- We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.
- Subjects :
- Amino Acid Sequence
Base Sequence
DNA chemistry
Electrophoretic Mobility Shift Assay
Fluorescence Polarization
Molecular Sequence Data
Oligonucleotides
Peptides chemistry
Protein Structure, Tertiary
Proto-Oncogene Proteins c-jun chemistry
DNA metabolism
Peptides metabolism
Proto-Oncogene Proteins c-jun metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 13
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25778494
- Full Text :
- https://doi.org/10.1039/c5ob00318k