Back to Search
Start Over
Phylogenetic analysis of human metapneumovirus detected in hospitalized patients in Kuwait during the years 2009-2011.
- Source :
-
Journal of infection and public health [J Infect Public Health] 2015 Sep-Oct; Vol. 8 (5), pp. 448-57. Date of Electronic Publication: 2015 Mar 12. - Publication Year :
- 2015
-
Abstract
- Background: Human metapneumovirus (hMPV) is an important cause of both upper and lower respiratory tract infections (RTIs) in all age groups. Children, elderly, and immunocompromised individuals are the most affected groups. HMPV infection accounts for 5% of hospitalized patients with respiratory tract infections in Kuwait. It is mostly detected among infants and elderly age groups, and both hMPV genotypes A and B circulate in Kuwait.<br />Methods: In this study, the genetic diversity of detected hMPV was evaluated, and a phylogenetic analysis based on partial nucleotide and amino acid sequences of the G gene was performed for hMPV detected among hospitalized patients with RTIs.<br />Results: Our results showed that 62% of hMPV sequences belonged to the A genotype and 38% to the B genotype. A2b and B2 subtypes were detected and circulated during the study period, whereas A1 and B1 subtypes were not detected. Based on nucleotide sequences of the G gene, most of hMPV strains (57%) were clustered with Indian strains, followed by Greek strains (24%) and Canadian strains (14%). One strain (5%) clustered within the B genotype but had different branches than B1 and B2 branches.<br />Conclusion: Our data showed the co-circulation of hMPV genotypes A2b and B2 in Kuwait with genetic diversity suggestive of evolution through negative selection.<br /> (Copyright © 2015 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Cluster Analysis
Female
Hospitalization
Humans
Infant
Infant, Newborn
Kuwait epidemiology
Male
Metapneumovirus genetics
Middle Aged
Molecular Epidemiology
Molecular Sequence Data
Paramyxoviridae Infections epidemiology
Selection, Genetic
Sequence Analysis, DNA
Sequence Homology
Young Adult
Genetic Variation
Glycoproteins genetics
Metapneumovirus classification
Metapneumovirus isolation & purification
Paramyxoviridae Infections virology
Phylogeny
Viral Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1876-035X
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of infection and public health
- Publication Type :
- Academic Journal
- Accession number :
- 25773766
- Full Text :
- https://doi.org/10.1016/j.jiph.2015.01.008