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Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet.
- Source :
-
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2015 May 01; Vol. 284 (3), pp. 345-53. Date of Electronic Publication: 2015 Mar 11. - Publication Year :
- 2015
-
Abstract
- Prenatal caffeine exposure (PCE) alters the hypothalamic-pituitary-adrenocortical (HPA) axis-associated neuroendocrine metabolic programming and induces an increased susceptibility to metabolic syndrome (MS) in intrauterine growth retardation (IUGR) offspring rats. High-fat diet (HFD) is one of the main environmental factors accounting for the incidence of MS. In this study, we aimed to clarify the gender-specific increase in susceptibility to MS in offspring rats after PCE with post-weaning HFD. Maternal Wistar rats were administered with caffeine (120mg/kg·d) from gestational day 11 until delivery. The offspring rats with normal diet or HFD were euthanized at postnatal week 24, and blood samples were collected. Results showed that PCE not only reduced serum adrenocorticotropic hormone (ACTH) and corticosterone levels, but also enhanced serum glucose, triglyceride and total cholesterol (TCH) concentrations in the offspring rats. Moreover, several interactions among PCE, HFD and gender were observed by a three-way ANOVA analysis. In PCE offspring, HFD could aggravate the degree of increased serum triglyceride level. Meanwhile, serum corticosterone levels of females were decreased more obviously than those of males in PCE offspring. The results also revealed interactions between HFD and gender in the levels of serum ACTH, triglyceride and TCH, which were changed more evidently in female HFD offspring. These results indicate that HFD could exacerbate the dysfunction of lipid metabolism and the susceptibility to MS induced by PCE, and the female offspring are more sensitive to HFD-induced neuroendocrine metabolic dysfunction than their male counterparts.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adrenocorticotropic Hormone blood
Age Factors
Analysis of Variance
Animal Nutritional Physiological Phenomena
Animals
Blood Glucose metabolism
Cholesterol blood
Corticosterone blood
Female
Gestational Age
Male
Metabolic Syndrome blood
Pregnancy
Rats, Wistar
Risk Assessment
Risk Factors
Sex Factors
Triglycerides blood
Weaning
Caffeine toxicity
Diet, High-Fat adverse effects
Maternal Exposure adverse effects
Metabolic Syndrome chemically induced
Prenatal Exposure Delayed Effects
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0333
- Volume :
- 284
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Toxicology and applied pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 25771125
- Full Text :
- https://doi.org/10.1016/j.taap.2015.03.002