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Chronic exposure to cigarette smoke causes extrapulmonary abnormalities in rats.
- Source :
-
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2015 Mar; Vol. 39 (2), pp. 864-70. Date of Electronic Publication: 2015 Mar 04. - Publication Year :
- 2015
-
Abstract
- Pathophysiological features of chronic obstructive pulmonary disease (COPD) include systemic abnormalities, such as weight loss and skeletal muscle wasting. Although cigarette smoke (CS) is a major risk factor in COPD, the systemic effects of CS exposure remain to be elucidated. In this study, rats were exposed to CS or smoke-free air for 12 weeks. CS-exposed rats developed emphysema and had significantly lower body weight and food intake than control rats. The plasma ghrelin levels significantly increased with an upregulation of gastric ghrelin mRNA expression induced by CS exposure. Further, we observed low plasma insulin-like growth factor-1 levels and high tumor necrosis factor-α levels. A significant reduction of skeletal muscle strength and an increase in the mRNA expression of catabolic factors was observed in CS-exposed rats. These results indicated that chronic CS exposure induced not only pulmonary emphysema but also systemic abnormalities related to muscle catabolism associated with inflammatory responses.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Body Weight drug effects
Cytokines blood
Eating drug effects
Emphysema blood
Emphysema metabolism
Gastric Mucosa metabolism
Ghrelin blood
Ghrelin genetics
Lung drug effects
Male
Muscle Proteins genetics
Muscle Weakness chemically induced
Muscle, Skeletal metabolism
Myostatin genetics
RNA, Messenger metabolism
Rats, Wistar
SKP Cullin F-Box Protein Ligases genetics
Stomach drug effects
Tripartite Motif Proteins
Ubiquitin-Protein Ligases genetics
Emphysema chemically induced
Muscle, Skeletal drug effects
Smoke adverse effects
Nicotiana adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7077
- Volume :
- 39
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Environmental toxicology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 25770835
- Full Text :
- https://doi.org/10.1016/j.etap.2015.02.016