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Real-time contrast ultrasound muscle perfusion imaging with intermediate-power imaging coupled with acoustically durable microbubbles.
- Source :
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Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography [J Am Soc Echocardiogr] 2015 Jun; Vol. 28 (6), pp. 718-26.e2. Date of Electronic Publication: 2015 Mar 11. - Publication Year :
- 2015
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Abstract
- Background: There is growing interest in limb contrast-enhanced ultrasound (CEU) perfusion imaging for the evaluation of peripheral artery disease. Because of low resting microvascular blood flow in skeletal muscle, signal enhancement during limb CEU is prohibitively low for real-time imaging. The aim of this study was to test the hypothesis that this obstacle can be overcome by intermediate- rather than low-power CEU when performed with an acoustically resilient microbubble agent.<br />Methods: Viscoelastic properties of Definity and Sonazoid were assessed by measuring bulk modulus during incremental increases in ambient pressure to 200 mm Hg. Comparison of in vivo microbubble destruction and signal enhancement at a mechanical index (MI) of 0.1 to 0.4 was performed by sequential reduction in pulsing interval from 10 to 0.05 sec during limb CEU at 7 MHz in mice and 1.8 MHz in dogs. Destruction was also assessed by broadband signal generation during passive cavitation detection. Real-time CEU perfusion imaging with destruction-replenishment was then performed at 1.8 MHz in dogs using an MI of 0.1, 0.2, or 0.3.<br />Results: Sonazoid had a higher bulk modulus than Definity (66 ± 12 vs 29 ± 2 kPa, P = .02) and exhibited less inertial cavitation (destruction) at MIs ≥ 0.2. On in vivo CEU, maximal signal intensity increased incrementally with MI for both agents and was equivalent between agents except at an MI of 0.1 (60% and 85% lower for Sonazoid at 7 and 1.8 MHz, respectively, P < .05). However, on progressive shortening of the pulsing interval, Definity was nearly completely destroyed at MIs ≥ 0.2 at 1.8 and 7 MHz, whereas Sonazoid was destroyed only at 1.8 MHz at MIs ≥ 0.3. As a result, real-time CEU perfusion imaging demonstrated approximately fourfold greater enhancement for Sonazoid at an MI of 0.3 to 0.4.<br />Conclusions: Robust signal enhancement during real-time CEU perfusion imaging of the limb is possible when using intermediate-power imaging coupled with a durable microbubble contrast agent.<br /> (Copyright © 2015 American Society of Echocardiography. All rights reserved.)
- Subjects :
- Animals
Blood Flow Velocity physiology
Computer Systems
Contrast Media
Dogs
Elastic Modulus radiation effects
Ferric Compounds radiation effects
Fluorocarbons radiation effects
Hardness radiation effects
Iron radiation effects
Materials Testing
Mice
Mice, Inbred C57BL
Microbubbles
Muscle, Skeletal blood supply
Oxides radiation effects
Reproducibility of Results
Sensitivity and Specificity
Sound
Viscosity radiation effects
Ferric Compounds chemistry
Fluorocarbons chemistry
Iron chemistry
Muscle, Skeletal diagnostic imaging
Muscle, Skeletal physiology
Oxides chemistry
Perfusion Imaging methods
Ultrasonography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6795
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
- Publication Type :
- Academic Journal
- Accession number :
- 25769666
- Full Text :
- https://doi.org/10.1016/j.echo.2015.02.002