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Postoperative pentagastrin-stimulated serum calcitonin concentrations in patients with medullary thyroid carcinoma: reoperations in patients with concentrations bordering the detection limit.
- Source :
-
Henry Ford Hospital medical journal [Henry Ford Hosp Med J] 1989; Vol. 37 (3-4), pp. 138-40. - Publication Year :
- 1989
-
Abstract
- The case reports on two patients with medullary thyroid carcinoma show that even postoperatively stimulated serum calcitonin (CT) concentrations near the detection limit (using a polyclonal antibody against synthetic CT) can demonstrate persistent disease. Stimulated CT concentrations can be lowered to nondetectable levels by a second and third operation if a meticulous technique is used for dissection of the lymph compartments. The patient can then be assumed to be cured. Diagnostic accuracy at very low CT concentrations can be improved by selective venous catheterization with blood sampling for CT after stimulation.
- Subjects :
- Adult
Carcinoma genetics
Carcinoma surgery
Female
Follow-Up Studies
Humans
Lymph Node Excision
Male
Multiple Endocrine Neoplasia genetics
Multiple Endocrine Neoplasia surgery
Postoperative Period
Radioimmunoassay
Reoperation
Thyroid Neoplasms genetics
Thyroid Neoplasms surgery
Calcitonin blood
Carcinoma diagnosis
Multiple Endocrine Neoplasia diagnosis
Pentagastrin
Thyroid Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0018-0416
- Volume :
- 37
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Henry Ford Hospital medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 2576947