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Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans.
- Source :
-
Blood [Blood] 2015 May 14; Vol. 125 (20), pp. 3193-201. Date of Electronic Publication: 2015 Mar 12. - Publication Year :
- 2015
-
Abstract
- Allogeneic antibodies against minor histocompatibility antigens encoded on the Y chromosome (HY-Abs) develop after hematopoietic cell transplant (HCT) of male recipients with female donors (F→M). However, the temporal association between HY-Ab development and chronic graft-versus-host disease (cGVHD) has yet to be elucidated. We studied 136 adult F→M HCT patients, with plasma prospectively collected through 3 years posttransplant, and measured immunoglobulin G against 6 H-Y antigens. Multiple HY-Abs were frequently detected beginning at 3 months posttransplant: 78 (57%) of F→M patients were seropositive for at least 1 of the 6 HY-Abs, and 3-month seropositivity for each HY-Ab was associated with a persistent seropositive response throughout the posttransplant follow-up period (P < .001 in each). There were no associations between pretransplant features and 3-month overall HY-Ab development. Detection of multiple HY-Abs at 3 months (represented by HY score) was significantly associated with an increased risk of cGVHD (P < .0001) and nonrelapse mortality (P < .01). Compared to clinical factors alone, the addition of HY score to clinical factors improved the predictive potential of cGVHD (P < .01). Monitoring HY-Ab development thus stratifies cGVHD risk in F→M HCT patients and may support preemptive prophylaxis therapy for cGVHD beginning at 3 months posttransplant.<br /> (© 2015 by The American Society of Hematology.)
- Subjects :
- Adult
Age Factors
Aged
Female
Graft vs Host Disease mortality
H-Y Antigen immunology
Humans
Isoantibodies blood
Male
Middle Aged
Patient Outcome Assessment
Prognosis
Proteomics
Time Factors
Transplantation, Homologous
Graft vs Host Disease diagnosis
Graft vs Host Disease etiology
Hematopoietic Stem Cell Transplantation adverse effects
Isoantibodies immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1528-0020
- Volume :
- 125
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Blood
- Publication Type :
- Academic Journal
- Accession number :
- 25766725
- Full Text :
- https://doi.org/10.1182/blood-2014-11-613323