Back to Search
Start Over
Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study.
- Source :
-
European journal of haematology [Eur J Haematol] 2016 Jan; Vol. 96 (1), pp. 36-45. Date of Electronic Publication: 2015 Mar 31. - Publication Year :
- 2016
-
Abstract
- Objective: We performed an external and multicentric validation of the predictive value of abdominal computed tomography (aCT) on time to first treatment (TTFT) in early stage chronic lymphocytic leukemia (CLL) patients.<br />Methods: aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISL trial (clinicaltrial.gov ID:NCT00917549).<br />Results: Fifty-five patients showed an abnormal aCT. Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT (P < 0.0001). At multivariate analysis, aCT (P = 0.011), β-2 microglobulin (P = 0.019), and CD38 expression (P = 0.047) correlated with TTFT. Following IWCLL 2008 criteria, 112 (61.9%) cases remained at Rai 0, while 69 (38.1%) satisfied the criteria of clinical monoclonal B-cell lymphocytosis (cMBL). Reclassified Rai 0 patients with an abnormal aCT showed a significantly shorter TTFT than those with a normal aCT (P < 0.0001). At multivariate analysis, only aCT (P = 0.011) correlated with TTFT. Eleven cMBL cases (15.9%) showed an abnormal aCT and were reclassified as small lymphocytic lymphomas (SLL); nonetheless, TTFT was similar for cMBLs and SLLs.<br />Conclusion: Our results confirm the ability of the abnormal aCT to predict progression in early stage cases.<br /> (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- ADP-ribosyl Cyclase 1 blood
Abdomen
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell blood
Male
Middle Aged
beta 2-Microglobulin blood
Leukemia, Lymphocytic, Chronic, B-Cell diagnostic imaging
Leukemia, Lymphocytic, Chronic, B-Cell therapy
Radiography, Abdominal
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0609
- Volume :
- 96
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 25753656
- Full Text :
- https://doi.org/10.1111/ejh.12545