The effect of re-operation on survival in patients with recurrent glioblastoma.

Authors :: Franceschi E
Bartolotti M
Tosoni A
Bartolini S
Sturiale C
Fioravanti A
Pozzati E
Galzio R
Talacchi A
Volpin L
Morandi L
Danieli D
Ermani M
Brandes AA
Source :: Anticancer research [Anticancer Res] 2015 Mar; Vol. 35 (3), pp. 1743-8.
Publication Year :: 2015
Abstract: Background: Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown.<br />Patients and Methods: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution.<br />Results: Two hundred and thirty-two patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors.<br />Conclusion: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.<br /> (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)