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The role of complement factor C3 in lipid metabolism.
- Source :
-
Molecular immunology [Mol Immunol] 2015 Sep; Vol. 67 (1), pp. 101-7. Date of Electronic Publication: 2015 Mar 06. - Publication Year :
- 2015
-
Abstract
- Abundant reports have shown that there is a strong relationship between C3 and C3a-desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic syndrome and diabetes. The data indicate that complement components, particularly C3, are involved in lipid metabolism. The C3 fragment, C3a-desArg, functions as a hormone that has insulin-like effects and facilitates triglyceride metabolism. Adipose tissue produces and regulates the levels of complement components, which promotes generation of inflammatory initiators such as the anaphylatoxins C3a and C5a. The anaphylatoxins trigger a cyto/chemokine response in proportion to the amount of adipose tissue present, and induce inflammation and mediate metabolic effects such as insulin resistance. These observations support the concept that complement is an important participant in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adipose Tissue metabolism
Adipose Tissue pathology
Apolipoproteins genetics
Apolipoproteins immunology
Apolipoproteins metabolism
Cardiovascular Diseases genetics
Cardiovascular Diseases metabolism
Cardiovascular Diseases pathology
Complement C3a genetics
Complement C3a metabolism
Complement C5a genetics
Complement C5a immunology
Complement C5a metabolism
Diabetes Mellitus genetics
Diabetes Mellitus metabolism
Diabetes Mellitus pathology
Gene Expression Regulation
Humans
Insulin Resistance immunology
Metabolic Syndrome genetics
Metabolic Syndrome metabolism
Metabolic Syndrome pathology
Obesity genetics
Obesity metabolism
Obesity pathology
Receptors, Complement genetics
Receptors, Complement immunology
Receptors, Complement metabolism
Risk Factors
Triglycerides genetics
Triglycerides immunology
Triglycerides metabolism
Adipose Tissue immunology
Cardiovascular Diseases immunology
Complement C3a immunology
Diabetes Mellitus immunology
Lipid Metabolism immunology
Metabolic Syndrome immunology
Obesity immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9142
- Volume :
- 67
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular immunology
- Publication Type :
- Academic Journal
- Accession number :
- 25746915
- Full Text :
- https://doi.org/10.1016/j.molimm.2015.02.027