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[Cardiac and breast diffuse large B-cell lymphoma with pericardial effusion and AV-block].
- Source :
-
[Rinsho ketsueki] The Japanese journal of clinical hematology [Rinsho Ketsueki] 2015 Jan; Vol. 56 (1), pp. 9-15. - Publication Year :
- 2015
-
Abstract
- Primary cardiac lymphoma is extremely rare and is associated with a poor prognosis. In most cases, cardiac involvement occurs as a late symptom and the diagnosis is thus delayed. We herein report a 35-year-old woman with cardiac diffuse large B-cell lymphoma (DLBCL) with breast infiltration. The patient was admitted to our hospital based on an initial presentation with dyspnea on exertion, chest pain, and a hard mass of the left breast. Echocardiography revealed a mass in the right atrium wall and interatrial septum, and massive pericardial effusion. ECG showed atrioventoricular block. We promptly performed a needle biopsy of the breast mass, which showed CD5-positive DLBCL, non-GCB type. The serum HIV reaction was negative. We thus diagnosed this patient as having cardiac and breast CD5-positive DLBCL, stage IVA, based on the massive pericardial effusion. The patient's prognosis was apparently poor. Therefore, she received 3 cycles of R-CHOP chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT), resulting in a complete response. In general, cardiac lymphoma is associated with high mortality and has a poor prognosis. This case demonstrates that rapid and appropriate diagnosis, and immediate intensive chemotherapy followed by PBSCT might be necessary for the treatment of extranodal lymphoma indicative of a poor prognosis.
- Subjects :
- Adult
Breast Neoplasms complications
Breast Neoplasms diagnosis
Female
Heart Neoplasms complications
Heart Neoplasms diagnosis
Heart Neoplasms pathology
Humans
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoma, Large B-Cell, Diffuse pathology
Neoplasm Staging
Pericardial Effusion diagnosis
Pericardial Effusion etiology
Peripheral Blood Stem Cell Transplantation
Treatment Outcome
Breast Neoplasms therapy
Heart Neoplasms therapy
Lymphoma, Large B-Cell, Diffuse therapy
Pericardial Effusion therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0485-1439
- Volume :
- 56
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- [Rinsho ketsueki] The Japanese journal of clinical hematology
- Publication Type :
- Academic Journal
- Accession number :
- 25745961
- Full Text :
- https://doi.org/10.11406/rinketsu.56.9