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A hypoxia efficient imidazole-based Ru(II) arene anticancer agent resistant to deactivation by glutathione.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2015 Apr 07; Vol. 44 (13), pp. 5969-73. - Publication Year :
- 2015
-
Abstract
- A slow hydrolyzing imidazole-based Ru(II)-arene complex [(L)Ru(II)(η(6)-p-cym)(Cl)](PF6) (1) with excellent stability in the extracellular chloride concentration shows better activity under hypoxia and strong resistance to glutathione (GSH) in vitro under hypoxic conditions. 1 arrests the cell cycle in sub G1 and G2/M phases and leads to apoptosis.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Apoptosis drug effects
Cell Cycle drug effects
Cell Hypoxia
Cell Survival drug effects
Coordination Complexes chemistry
Coordination Complexes pharmacology
Glutathione pharmacology
HeLa Cells
Humans
Hydrogen-Ion Concentration
Hydrolysis
MCF-7 Cells
Molecular Structure
Antineoplastic Agents chemical synthesis
Coordination Complexes chemical synthesis
Glutathione metabolism
Imidazoles chemistry
Ruthenium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9234
- Volume :
- 44
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 25742181
- Full Text :
- https://doi.org/10.1039/c4dt03983a