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Ethyl glucuronide and ethyl sulfate.
- Source :
-
Advances in clinical chemistry [Adv Clin Chem] 2014; Vol. 67, pp. 47-71. Date of Electronic Publication: 2014 Nov 04. - Publication Year :
- 2014
-
Abstract
- Alcohol misuse is associated with significant morbidity and mortality. Although clinical history, examination, and the use of self-report questionnaires may identify subjects with harmful patterns of alcohol use, denial or under-reporting of alcohol intake is common. Existing biomarkers for detecting alcohol misuse include measurement of blood or urine ethanol for acute alcohol consumption, and carbohydrate-deficient transferrin and gamma-glutamyl transferase for chronic alcohol misuse. There is a need for a biomarker that can detect excessive alcohol consumption in the timeframe between 1 day and several weeks. Ethyl glucuronide (EtG) is a direct metabolite of ethanol detectable in urine for up to 90 h and longer in hair. Because EtG has high specificity for excess alcohol intake, it has great potential for use in detecting "binge" drinking. Using urine or hair, this noninvasive marker has a role in a variety of clinical and forensic settings.<br /> (© 2014 Elsevier Inc. All rights reserved.)
- Subjects :
- Automobile Driving
Autopsy methods
Binge Drinking
Biomarkers analysis
Biomarkers blood
Chromatography, Reverse-Phase methods
Ethanol metabolism
False Positive Reactions
Female
Fetal Alcohol Spectrum Disorders
Glucuronates urine
Hair chemistry
Humans
Liver Diseases, Alcoholic
Liver Transplantation
Male
Mass Spectrometry methods
Sex Offenses
Sulfuric Acid Esters urine
Time Factors
Urinary Tract Infections
Alcohol Drinking
Biomarkers urine
Ethanol pharmacokinetics
Glucuronates analysis
Sulfuric Acid Esters analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2423
- Volume :
- 67
- Database :
- MEDLINE
- Journal :
- Advances in clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25735859
- Full Text :
- https://doi.org/10.1016/bs.acc.2014.09.006