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Alterations in renal hemodynamics during chronic and acute beta-blockade in humans.
- Source :
-
American journal of hypertension [Am J Hypertens] 1989 Nov; Vol. 2 (11 Pt 2), pp. 233S-236S. - Publication Year :
- 1989
-
Abstract
- Renal hemodynamics of hypertensive patients are characterized by an increased renal vascular resistance (RVR), resulting in low renal plasma flow (RPF). Normal glomerular filtration rate (GFR) is maintained through an increased filtration fraction (FF). This pattern may have long term harmful consequences for the kidneys. Propranolol, given in the short- or long-term, lowers both RPF and GFR. Pindolol, as well as so called cardioselective beta-blockers and labetalol, alter renal hemodynamics only slightly, if not at all. In some studies, nadolol has been shown to increase RPF, leaving GFR unchanged. A new beta-blocker, tertatolol, seems to consistently increase RPF and GFR. These different renal actions of various beta-blockers are poorly explained. They may be, however, of clinical significance, in the short term for patients with already impaired renal function, and possibly over the long term for other hypertensive patients.
- Subjects :
- Adrenergic beta-Antagonists therapeutic use
Anti-Arrhythmia Agents pharmacology
Humans
Hypertension, Renovascular drug therapy
Propanolamines therapeutic use
Renal Circulation drug effects
Adrenergic beta-Antagonists pharmacology
Glomerular Filtration Rate drug effects
Hemodynamics
Hypertension drug therapy
Kidney drug effects
Propanolamines pharmacology
Thiophenes
Subjects
Details
- Language :
- English
- ISSN :
- 0895-7061
- Volume :
- 2
- Issue :
- 11 Pt 2
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 2573369
- Full Text :
- https://doi.org/10.1093/ajh/2.11.233s