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Genome level analysis of bacteriocins of lactic acid bacteria.
- Source :
-
Computational biology and chemistry [Comput Biol Chem] 2015 Jun; Vol. 56, pp. 1-6. Date of Electronic Publication: 2015 Feb 23. - Publication Year :
- 2015
-
Abstract
- Bacteriocins are antimicrobial peptides which are ribosomally synthesized by mainly all bacterial species. LABs (lactic acid bacteria) are a diverse group of bacteria that include around 20 genera of various species. Though LABs have a tremendous potential for production of anti-microbial peptides, this group of bacteria is still underexplored for bacteriocins. To study the diversity among bacteriocin encoding clusters and the putative bacteriocin precursors, genome mining was performed on 20 different species of LAB not reported to be bacteriocin producers. The phylogenetic tree of gyrB, rpoB, and 16S rRNA were constructed using MEGA6 software to analyze the diversity among strains. Putative bacteriocins operons identified were found to be diverse and were further characterized on the basis of physiochemical properties and the secondary structure. The presence of at least two cysteine residues in most of the observed putative bacteriocins leads to disulphide bond formation and provide stability. Our data suggests that LABs are prolific source of low molecular weight non modified peptides.<br /> (Copyright © 2015. Published by Elsevier Ltd.)
- Subjects :
- Bacteriocins chemistry
Bacteriocins metabolism
DNA, Bacterial genetics
Genomics
Lactic Acid metabolism
Lactobacillus chemistry
Lactobacillus metabolism
Leuconostoc chemistry
Leuconostoc metabolism
Multigene Family
Phylogeny
Protein Structure, Secondary
RNA, Ribosomal, 16S genetics
Streptococcus chemistry
Streptococcus metabolism
Bacteriocins genetics
Lactobacillus genetics
Leuconostoc genetics
Streptococcus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1476-928X
- Volume :
- 56
- Database :
- MEDLINE
- Journal :
- Computational biology and chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25733445
- Full Text :
- https://doi.org/10.1016/j.compbiolchem.2015.02.013