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Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.
- Source :
-
Fitoterapia [Fitoterapia] 2015 Apr; Vol. 102, pp. 149-55. Date of Electronic Publication: 2015 Feb 27. - Publication Year :
- 2015
-
Abstract
- Bioassay guided fractionation of Hypericum riparium leaves extract has resulted in the isolation and characterization of three new compounds namely chipericumin E (1), hyperenone C (3), and hyperixanthone (5), together with twenty known compounds. Their structures were elucidated based on comprehensive interpretation of spectroscopic and spectrometric data. Compounds 1-4, and 6-8 displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxic effects on the human gastric cell line BGC-823 with IC50 values ranging from 6.54 to 18.50μM.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Anti-Bacterial Agents isolation & purification
Antineoplastic Agents, Phytogenic isolation & purification
Cell Line, Tumor
Humans
Lactones chemistry
Lactones isolation & purification
Methicillin-Resistant Staphylococcus aureus drug effects
Molecular Structure
Plant Leaves chemistry
Plants, Medicinal chemistry
Spiro Compounds chemistry
Spiro Compounds isolation & purification
Xanthones isolation & purification
Anti-Bacterial Agents chemistry
Antineoplastic Agents, Phytogenic chemistry
Hypericum chemistry
Plant Extracts chemistry
Xanthones chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 102
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 25732351
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.02.006