Back to Search
Start Over
Ocular Surface Disease in Glaucoma: Effect of Polypharmacy and Preservatives.
- Source :
-
Optometry and vision science : official publication of the American Academy of Optometry [Optom Vis Sci] 2015 Sep; Vol. 92 (9), pp. e222-6. - Publication Year :
- 2015
-
Abstract
- Purpose: To evaluate the prevalence of ocular surface disease (OSD) in glaucoma and nonglaucoma subjects using different clinical tests and to determine the effect of number of antiglaucoma medications and preservatives on OSD.<br />Methods: This is a cross-sectional, case-comparison study at the Eye Clinic of the University of Malaya Medical Centre, Malaysia, between June 2012 and January 2013. Glaucoma subjects (n = 105) using topical antiglaucoma medications were compared with control subjects (n = 102) who were not on any topical medications. The presence of OSD was assessed using the tear film breakup time (TBUT) test, corneal staining, Schirmer test, and Ocular Surface Disease Index (OSDI) questionnaire grading.<br />Results: The prevalence of OSD varied from 37 to 91% in the glaucoma group, depending on the type of clinical test. More subjects in the glaucoma group had corneal staining (63% vs. 36%, p = 0.004), abnormal Schirmer tests (39% vs. 25%, p = 0.049), and moderate OSDI symptoms (17% vs. 7%, p = 0.028). The percentage with abnormal TBUT increased with higher numbers of topical medications and was high with both benzalkonium chloride-containing and preservative-free eye drops (90% and 94%, respectively, both p < 0.001). Benzalkonium chloride was associated with a nearly three times higher odds ratio of showing abnormal OSDI.<br />Conclusions: Ocular surface disease is common in those using topical antiglaucoma medications. Abnormal TBUT is associated with increasing number of eye drops and benzalkonium chloride-containing eye drops, although this also occurs with the use of preservative-free eye drops.
- Subjects :
- Aged
Antihypertensive Agents therapeutic use
Conjunctival Diseases chemically induced
Conjunctival Diseases diagnosis
Corneal Diseases chemically induced
Corneal Diseases diagnosis
Cross-Sectional Studies
Eyelid Diseases chemically induced
Eyelid Diseases diagnosis
Female
Glaucoma drug therapy
Humans
Intraocular Pressure drug effects
Male
Middle Aged
Ophthalmic Solutions
Polypharmacy
Prevalence
Surveys and Questionnaires
Tears
Antihypertensive Agents adverse effects
Benzalkonium Compounds adverse effects
Conjunctival Diseases epidemiology
Corneal Diseases epidemiology
Eyelid Diseases epidemiology
Glaucoma complications
Preservatives, Pharmaceutical adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1538-9235
- Volume :
- 92
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Optometry and vision science : official publication of the American Academy of Optometry
- Publication Type :
- Academic Journal
- Accession number :
- 25730335
- Full Text :
- https://doi.org/10.1097/OPX.0000000000000542