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Oestrogen hormone receptors in focal nodular hyperplasia.
- Source :
-
HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2015 Jun; Vol. 17 (6), pp. 502-7. Date of Electronic Publication: 2015 Feb 28. - Publication Year :
- 2015
-
Abstract
- Background: The role of hormones in focal nodular hyperplasia (FNH) has been investigated with conflicting results.<br />Objective: The aim of this study was to evaluate oestrogen and progesterone receptor immunohistochemical expression in FNH and surrounding normal liver (control material).<br />Methods: Biopsy materials from FNH and control tissue were investigated using an immunostainer. Receptor expression was graded as the proportion score (percentage of nuclear staining) and oestrogen receptor intensity score.<br />Results: Study material included tissue from 11 resected FNH lesions and two core biopsies in 13 patients (two male). Twelve samples showed oestrogen receptor expression. The percentage of nuclear oestrogen receptor staining was <33% in eight FNH biopsies, 34-66% in two FNH biopsies, and >67% in both core biopsies. The better staining in core biopsies relates to limitations of the staining technique imposed by the fibrous nature of larger resected FNH. Control samples from surrounding tissue were available for nine of the resected specimens and all showed oestrogen receptor expression. Progesterone receptor expression was negligible in FNH and control samples.<br />Conclusions: By contrast with previous studies, the majority of FNH and surrounding liver in this cohort demonstrated oestrogen receptor nuclear staining. The implications of this for continued oral contraceptive use in women of reproductive age with FNH remain uncertain given the lack of consistent reported growth response to oestrogen stimulation or withdrawal.<br /> (© 2015 International Hepato-Pancreato-Biliary Association.)
- Subjects :
- Adult
Biopsy
Cell Nucleus chemistry
Contraceptives, Oral, Hormonal adverse effects
Female
Focal Nodular Hyperplasia pathology
Focal Nodular Hyperplasia surgery
Hepatectomy
Humans
Immunohistochemistry
Liver pathology
Liver surgery
Male
Middle Aged
Predictive Value of Tests
Receptors, Progesterone analysis
Focal Nodular Hyperplasia metabolism
Liver chemistry
Receptors, Estrogen analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2574
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- HPB : the official journal of the International Hepato Pancreato Biliary Association
- Publication Type :
- Academic Journal
- Accession number :
- 25728618
- Full Text :
- https://doi.org/10.1111/hpb.12387