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Cardiorenal Syndrome and the Role of the Bone-Mineral Axis and Anemia.
- Source :
-
American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2015 Aug; Vol. 66 (2), pp. 196-205. Date of Electronic Publication: 2015 Feb 26. - Publication Year :
- 2015
-
Abstract
- The association between chronic kidney disease (CKD) and cardiovascular disease (CVD) is well established, and there is mounting evidence of interorgan cross talk that may accelerate pathologic processes and the progression of organ dysfunction in both systems. This process, termed cardiorenal syndrome (CRS) by the Acute Dialysis Quality Initiative, is considered a major health problem: patients with CKD and CVD are at much higher risk of mortality than patients with either condition alone. To date, the majority of CRS research has focused on neurohormonal mechanisms and hemodynamic alterations. However, mounting evidence suggests that abnormalities in the normal pathophysiology of the bone-mineral axis, iron, and erythropoietin play a role in accelerating CKD and CVD. The goal of this article is to review the role and interrelated effects of the bone-mineral axis and anemia in the pathogenesis of chronic CRS.<br /> (Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Anemia complications
Calcifediol metabolism
Calcitriol metabolism
Cardio-Renal Syndrome complications
Cardiovascular Diseases complications
Cardiovascular Diseases metabolism
Fibroblast Growth Factor-23
Fibroblast Growth Factors metabolism
Humans
Parathyroid Hormone metabolism
Renal Insufficiency, Chronic complications
Renal Insufficiency, Chronic metabolism
Anemia metabolism
Bone and Bones metabolism
Calcium metabolism
Cardio-Renal Syndrome metabolism
Erythropoietin metabolism
Iron metabolism
Phosphates metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1523-6838
- Volume :
- 66
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of kidney diseases : the official journal of the National Kidney Foundation
- Publication Type :
- Academic Journal
- Accession number :
- 25727384
- Full Text :
- https://doi.org/10.1053/j.ajkd.2014.12.016