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Immunogenicity of the Bivalent Oral Cholera Vaccine Shanchol in Haitian Adults With HIV Infection.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2015 Sep 01; Vol. 212 (5), pp. 779-83. Date of Electronic Publication: 2015 Feb 26. - Publication Year :
- 2015
-
Abstract
- We evaluated immune responses following bivalent oral cholera vaccination (Shanchol [Shantha Biotechnics]; BivWC) in a cohort of 25 human immunodeficiency virus (HIV)-infected adults in Haiti. Compared with adults without HIV infection, vaccination in HIV-infected individuals resulted in lower vibriocidal responses against Vibrio cholerae O1, and there was a positive relationship between the CD4(+) T-cell count and vibriocidal responses following vaccination. Nevertheless, seroconversion occurred at a rate of 65% against the Ogawa serotype and 74% against the Inaba serotype in adults with HIV infection. These results suggest that the vaccine retains substantial immunogenicity in adults with HIV infection and may benefit this population by protecting against cholera.<br /> (© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Administration, Oral
Adult
Blood Bactericidal Activity
CD4 Lymphocyte Count
Cholera Vaccines administration & dosage
Cohort Studies
Female
HIV Infections complications
Haiti
Humans
Immunoglobulin A blood
Male
Microbial Viability
Middle Aged
Cholera prevention & control
Cholera Vaccines immunology
HIV Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 212
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 25722294
- Full Text :
- https://doi.org/10.1093/infdis/jiv108