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Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease.
- Source :
-
Neurology [Neurology] 2015 Mar 24; Vol. 84 (12), pp. 1254-60. Date of Electronic Publication: 2015 Feb 25. - Publication Year :
- 2015
-
Abstract
- Objectives: To determine whether an MRI-based Alzheimer disease (AD) signature biomarker can detect tau-related neurodegeneration in preclinical AD, and to assess whether AD signature cortical thinning is associated with cognitive changes in cognitively normal (CN) older individuals.<br />Methods: In a large cohort of CN individuals (n = 188), we measured the hippocampal volume and cortical thickness within independently defined AD signature regions. We cross-sectionally assessed the associations between AD signature cortical thinning or hippocampal atrophy with CSF biomarkers of tau (increased tau) and β-amyloid (Aβ) (decreased Aβ42). We also examined the impact of AD signature cortical thinning or other biomarker changes (i.e., hippocampal atrophy, reduced CSF Aβ42, or increased CSF tau) on cognitive performance in CN individuals.<br />Results: Elevated CSF tau was associated with AD signature cortical thinning but not hippocampal atrophy. In contrast, decreased CSF Aβ42 was associated with hippocampal loss but not AD signature cortical thinning. In addition, AD signature cortical thinning was associated with lower visuospatial performance. Reduced CSF Aβ42 was related to poorer performance on episodic memory.<br />Conclusions: Spatially distinct neurodegeneration is associated with Aβ and tau pathology in preclinical AD. Aβ deposition and AD signature cortical atrophy independently affect cognition in CN older individuals.<br /> (© 2015 American Academy of Neurology.)
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease pathology
Alzheimer Disease physiopathology
Atrophy pathology
Biomarkers cerebrospinal fluid
Cerebral Cortex physiopathology
Cohort Studies
Female
Hippocampus physiopathology
Humans
Magnetic Resonance Imaging
Male
Alzheimer Disease diagnosis
Amyloid beta-Peptides cerebrospinal fluid
Cerebral Cortex pathology
Hippocampus pathology
Peptide Fragments cerebrospinal fluid
Prodromal Symptoms
tau Proteins cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 84
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 25716355
- Full Text :
- https://doi.org/10.1212/WNL.0000000000001401