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Dietary intake of carotenoids and risk of type 2 diabetes.
- Source :
-
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2015 Apr; Vol. 25 (4), pp. 376-81. Date of Electronic Publication: 2014 Dec 31. - Publication Year :
- 2015
-
Abstract
- Background and Aims: Carotenoids may reduce diabetes risk, due to their antioxidant properties. However, the association between dietary carotenoids intake and type 2 diabetes risk is still unclear. Therefore, the objective of this study was to examine whether higher dietary carotenoid intakes associate with reduced type 2 diabetes risk.<br />Methods and Results: Data from 37,846 participants of the European Prospective Investigation into Cancer and Nutrition- Netherlands study were analyzed. Dietary intakes of β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein & zeaxanthin and the sum of these carotenoids were assessed using a validated food frequency questionnaire. Incident type 2 diabetes was mainly self-reported, and verified against general practitioner information. Mean ±SD total carotenoid intake was 10 ± 4 mg/day. During a mean ±SD follow-up of 10 ± 2 years, 915 incident cases of type 2 diabetes were ascertained. After adjustment for age, sex, diabetes risk factors, dietary intake, waist circumference and BMI, higher β-carotene intakes associated inversely with diabetes risk [Hazard Ratio quartile 4 versus quartile 1 (HR(Q4)): 0.78 (95%CI:0.64,0.95), P-linear trend 0.01]. For α-carotene, a borderline significant reduced risk was observed, with a HR(Q4) of 0.85 (95%CI:0.70,1.03), and P-linear trend 0.05. β-cryptoxanthin, lycopene, lutein & zeaxanthin, and the sum of all carotenoids did not associate with diabetes risk.<br />Conclusions: This study shows that diets high in β-carotene and α-carotene are associated with reduced type 2 diabetes in generally healthy men and women.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Cryptoxanthins administration & dosage
Energy Metabolism
Female
Follow-Up Studies
Humans
Incidence
Lutein administration & dosage
Lycopene
Male
Middle Aged
Netherlands epidemiology
Nutrition Assessment
Prospective Studies
Risk Factors
Surveys and Questionnaires
Zeaxanthins administration & dosage
beta Carotene administration & dosage
Antioxidants administration & dosage
Carotenoids administration & dosage
Diabetes Mellitus, Type 2 epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1590-3729
- Volume :
- 25
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nutrition, metabolism, and cardiovascular diseases : NMCD
- Publication Type :
- Academic Journal
- Accession number :
- 25716098
- Full Text :
- https://doi.org/10.1016/j.numecd.2014.12.008