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Investigation into the age-dependence of release of serotonin and noradrenaline in the rat brain cortex and of autoreceptor-mediated modulation of release.
- Source :
-
Neuropharmacology [Neuropharmacology] 1989 Aug; Vol. 28 (8), pp. 811-5. - Publication Year :
- 1989
-
Abstract
- Slices of cerebral cortex from young adult and aged rats, preincubated with [3H]serotonin or [3H]noradrenaline were superfused and the electrically (3 Hz) evoked overflow of tritium and its modulation by the respective agonists and antagonists were studied. The electrically evoked overflow in slices preincubated with [3H]serotonin from 2.5-year-old rats was smaller (by about 35%) than in slices from 3-month-old animals. No difference was found for the inhibition by serotonin and the facilitation by metitepine of the evoked overflow and for the metitepine-induced shift of the concentration-response curve for serotonin to the right. There was no difference between slices preincubated with [3H]noradrenaline from 3 months, 1, 2 and 2.5-year-old rats, with respect to the electrically evoked overflow, its inhibition and facilitation by noradrenaline and phentolamine, respectively, and the phentolamine-induced shift of the concentration-response curve for noradrenaline to the right. The present results suggest that the release of serotonin is reduced in the cerebral cortex of aged rats whereas the release of noradrenaline and the autoreceptor-mediated modulation of the release of either monoamine is not altered.
- Subjects :
- Adrenergic alpha-Agonists pharmacology
Adrenergic alpha-Antagonists pharmacology
Animals
Cerebral Cortex physiology
Electric Stimulation
In Vitro Techniques
Male
Methiothepin pharmacology
Phentolamine pharmacology
Rats
Rats, Inbred Strains
Aging physiology
Cerebral Cortex metabolism
Norepinephrine metabolism
Serotonin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0028-3908
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Neuropharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2571104
- Full Text :
- https://doi.org/10.1016/0028-3908(89)90172-x