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n-back task performance and corresponding brain-activation patterns in women with restrictive and bulimic eating-disorder variants: preliminary findings.
- Source :
-
Psychiatry research [Psychiatry Res] 2015 Apr 30; Vol. 232 (1), pp. 84-91. Date of Electronic Publication: 2015 Feb 07. - Publication Year :
- 2015
-
Abstract
- Eating disorder (ED) variants characterized by "binge-eating/purging" symptoms differ from "restricting-only" variants along diverse clinical dimensions, but few studies have compared people with these different eating-disorder phenotypes on measures of neurocognitive function and brain activation. We tested the performances of 19 women with "restricting-only" eating syndromes and 27 with "binge-eating/purging" variants on a modified n-back task, and used functional magnetic resonance imaging (fMRI) to examine task-induced brain activations in frontal regions of interest. When compared with "binge-eating/purging" participants, "restricting-only" participants showed superior performance. Furthermore, in an intermediate-demand condition, "binge-eating/purging" participants showed significantly less event-related activation than did "restricting-only" participants in a right posterior prefrontal region spanning Brodmann areas 6-8-a region that has been linked to planning of motor responses, working memory for sequential information, and management of uncertainty. Our findings suggest that working memory is poorer in eating-disordered individuals with binge-eating/purging behaviors than in those who solely restrict food intake, and that observed performance differences coincide with interpretable group-based activation differences in a frontal region thought to subserve planning and decision making.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Bulimia psychology
Feeding Behavior psychology
Feeding and Eating Disorders psychology
Female
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Task Performance and Analysis
Young Adult
Brain physiopathology
Bulimia physiopathology
Executive Function physiology
Feeding and Eating Disorders physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7123
- Volume :
- 232
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 25707581
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2015.01.022