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Renal and hormonal effects of alpha 1-adrenoceptor blockade by bunazosin in essential hypertension.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1989; Vol. 36 (6), pp. 575-8. - Publication Year :
- 1989
-
Abstract
- The renal and hormonal effects of the alpha 1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.
- Subjects :
- Administration, Oral
Adrenergic alpha-Antagonists administration & dosage
Adrenergic alpha-Antagonists pharmacology
Adult
Atrial Natriuretic Factor blood
Creatinine blood
Glomerular Filtration Rate drug effects
Humans
Hypertension physiopathology
Kidney blood supply
Norepinephrine blood
Quinazolines administration & dosage
Quinazolines pharmacology
Regional Blood Flow drug effects
Vascular Resistance drug effects
Adrenergic alpha-Antagonists therapeutic use
Blood Pressure drug effects
Hypertension drug therapy
Quinazolines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0031-6970
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 2570699
- Full Text :
- https://doi.org/10.1007/BF00637738