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Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2015 Dec; Vol. 21 (14), pp. 1761-70. Date of Electronic Publication: 2015 Feb 19. - Publication Year :
- 2015
-
Abstract
- Background: Cerebrospinal fluid (CSF) biomarkers have been suggested to predict multiple sclerosis (MS) after clinically isolated syndromes, but studies investigating long-term prognosis are needed.<br />Objective: To assess the predictive ability of CSF biomarkers with regard to MS development and long-term disability after optic neuritis (ON).<br />Methods: Eighty-six patients with ON as a first demyelinating event were included retrospectively. Magnetic resonance imaging (MRI), CSF leukocytes, immunoglobulin G index and oligoclonal bands were registered. CSF levels of chitinase-3-like-1, osteopontin, neurofilament light-chain, myelin basic protein, CCL2, CXCL10, CXCL13 and matrix metalloproteinase-9 were measured by enzyme-linked immunosorbent assay. Patients were followed up after 13.6 (range 9.6-19.4) years and 81.4% were examined, including Expanded Disability Status Scale and MS functional composite evaluation. 18.6% were interviewed by phone. Cox regression, multiple regression and Spearman correlation analyses were used.<br />Results: Forty-six (53.5%) developed clinically definite MS (CDMS) during follow-up. In a multivariate model MRI (p=0.0001), chitinase 3-like 1 (p=0.0033) and age (p=0.0194) combined predicted CDMS best. Neurofilament light-chain predicted long-term disability by the multiple sclerosis severity scale (p=0.0111) and nine-hole-peg-test (p=0.0202). Chitinase-3-like-1 predicted long-term cognitive impairment by the paced auditory serial addition test (p=0.0150).<br />Conclusion: Neurofilament light-chain and chitinase-3-like-1 were significant predictors of long-term physical and cognitive disability. Furthermore, chitinase-3-like-1 predicted CDMS development. Thus, these molecules hold promise as clinically valuable biomarkers after ON as a first demyelinating event.<br /> (© The Author(s), 2015.)
- Subjects :
- Adolescent
Adult
Biomarkers cerebrospinal fluid
Chitinase-3-Like Protein 1
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Severity of Illness Index
Young Adult
Adipokines cerebrospinal fluid
Disease Progression
Lectins cerebrospinal fluid
Multiple Sclerosis cerebrospinal fluid
Neurofilament Proteins cerebrospinal fluid
Optic Neuritis cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 21
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 25698172
- Full Text :
- https://doi.org/10.1177/1352458515574148