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A PE_PGRS33 protein of Mycobacterium tuberculosis: an ideal target for future tuberculosis vaccine design.
- Source :
-
Expert review of vaccines [Expert Rev Vaccines] 2015 May; Vol. 14 (5), pp. 699-711. Date of Electronic Publication: 2015 Feb 19. - Publication Year :
- 2015
-
Abstract
- It is known that cellular immune response is relevant to fight against tuberculosis (TB); hence, identification of mycobacterial antigens that induce a protective immune cellular response is of great interest, especially for the development of effective TB vaccines. Genomic data have an impact on the identification of potential antigens as new vaccine targets. In this review, we summarize the current knowledge about the advances in new TB vaccine designs as well as the features reported for the pro-glu_polymorphic GC-rich sequence (PE_PGRS33) protein, considering this molecule as a prototype of the PE_PGRS family to better understand the biological function of this protein family that could be considered an ideal target for future vaccine design.
- Subjects :
- Drug Discovery trends
Humans
Immunity, Cellular
Tuberculosis epidemiology
Tuberculosis prevention & control
Tuberculosis Vaccines isolation & purification
Vaccines, Subunit immunology
Vaccines, Subunit isolation & purification
Antigens, Bacterial immunology
Bacterial Proteins immunology
Mycobacterium tuberculosis immunology
Tuberculosis Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8395
- Volume :
- 14
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Expert review of vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 25693607
- Full Text :
- https://doi.org/10.1586/14760584.2015.1015995